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. 2015 Jan 8;96(1):136–146. doi: 10.1016/j.ajhg.2014.12.010

Figure 1.

Figure 1

Association between HLA Loci and Narcolepsy

(A) Association of SNPs in the HLA region (Chr6: 29–36 Mb) reveals an overwhelming signal peaking at the level of HLA-DQB1 in white (from Immunochip, see Faraco et al.39) and chinese (from Affymetrix CHB data, see Han et al.5) individuals. Extended LD and association signal within the HLA-DR-DQ region obscure all other signals.

(B) After conditioning for HLA-DRB1, HLA-DQA1, and HLA-DQB1 (significant alleles from the stepwise analysis), a residual association is seen in the HLA-DP region.

(C) After conditioning for all significant HLA class II alleles, a remaining association is seen in the HLA class I region and is most visible proximal to HLA-B. A possible additional peak is seen in white individuals only in the vicinity of PSORS1.