Table 3.

The Top Genetic Variants Identified by S_Het and S_Hom in the COGENT BP Consortium by First Performing Meta-analysis and then S_Het and S_Hom

Chr	SNP	POS	Genes	Effect Allele	Freq	Meta-analysis HTN			Meta-analysis SBP			Meta-analysis DBP			SHom	SHet
						beta	SE	p	beta	SE	p	beta	SE	p	p	p
Loci Reaching Genome-wide Significance
4	rs11725861	54497062	CHIC2	A	0.84	0.04	0.03	2.16 × 10−1	0.79	0.22	2.89 × 10−4	−0.18	0.13	1.63 × 10−1	2.56 × 10−1	8.45 × 10−9
7	rs11564022	27303571	HOXA-EVX1	T	0.23	−0.12	0.02	2.16 × 10−6	−0.89	0.19	1.83 × 10−6	−0.60	0.11	7.66 × 10−8	2.35 × 10−9	1.34 × 10−8
7	rs11977526	45974635	IGFBP1, IGFBP3	A	0.32	−0.01	0.02	5.30 × 10−1	−0.37	0.18	3.73 × 10−2	0.30	0.11	4.62 × 10−3	8.21 × 10−1	1.87 × 10−8
8	rs2446849	95172673	CDH17	T	0.80	−0.06	0.03	3.00 × 10−2	−0.63	0.20	2.00 × 10−3	0.22	0.12	6.75 × 10−2	2.11 × 10−1	7.01 × 10−9
Loci Reaching Suggestive Significance
3	rs10049492	53571572	CACNA1D	A	0.74	0.12	0.03	1.42 × 10−5	0.85	0.19	1.74 × 10−5	0.57	0.12	1.77 × 10−6	7.11 × 10−8	4.60 × 10−7
5	rs6886515	30702383	none	A	0.61	0.11	0.02	4.61 × 10−7	0.71	0.17	2.46 × 10−5	0.40	0.10	6.02 × 10−5	7.15 × 10−8	4.63 × 10−7
6	rs9401512	122707473	HSF2/PKIB	T	0.30	0.00	0.02	9.17 × 10−1	0.44	0.17	1.04 × 10−2	−0.23	0.10	2.75 × 10−2	9.43 × 10−1	5.75 × 10−8
11	rs11041530	7658079	CYB5R2	C	0.12	−0.09	0.03	9.83 × 10−3	−1.35	0.25	4.04 × 10−8	−0.54	0.15	2.65 × 10−4	9.08 × 10−6	2.55 × 10−7
12	rs11837544	93192534	PLXNC1	A	0.20	−0.01	0.03	5.89 × 10−1	−0.50	0.20	1.36 × 10−2	0.27	0.12	2.28 × 10−2	9.37 × 10−1	6.89 × 10−8
17	rs430685	42214309	GOSR2/WNT3	T	0.02	−0.42	0.14	2.65 × 10−3	1.26	0.84	1.33 × 10−1	1.51	0.50	2.64 × 10−3	8.07 × 10−1	5.77 × 10−8