Table 2.
Serum cytokine concentrations and PaO2/FiO2 on enrolment and at 48 h during hospitalisation according to study groups
| Simvastatin n=19 |
Placebo n=15 |
p Value | |
|---|---|---|---|
| Within 24 h of admission | |||
| PaO2/FiO2 | 276.1 (261–299) | 276.3 (243–320) | 0.90 |
| TNF-α (pg/mL) | 24 (22.3–61.7) | 30.6 (20.5–38) | 0.96 |
| IL-6 (pg/mL) | 700 (171–1908) | 362 (239–515) | 0.91 |
| IL-10 (pg/mL) | 8.35 (1.5–38.8) | 3.2 (2.4–8.3) | 0.17 |
| At 48 h during hospitalisation | |||
| PaO2/FiO2* | 300 (285–374) | 338.1 (314–401) | 0.37 |
| CRP (mg/dL) | 151.2 (59.5–243.6) | 69.4 (27.5–212.2) | 0.23 |
| TNF-α (pg/mL)* | 19.9 (16.7–40.8) | 20.6 (15.8–25.5) | 0.58 |
| IL-6 (pg/mL)* | 141 (8–192) | 66 (37.5–97) | 0.64 |
| IL-10 (pg/mL)* | 1.31 (0.4–3.8) | 1.16 (0.45–2.2) | 0.61 |
CRP levels at baseline were not available.
*p Values for ANCOVA analysis for PaO2/FiO2, TNF-α, IL-6 and IL-10 were 0.33, 0.97, 0.31 and 0.55, respectively. Data are reported as median (IQR).
ANCOVA, analysis of covariance; CRP, C reactive protein; FiO2, fractional inspired oxygen; IL, interleukin; PaO2, partial pressure of arterial oxygen; TNF, tumour necrosis factor.