Table 2. Systematic review of efficacy of transepithelial (TE) corneal collagen crosslinking.
| Lead Author | Year | Study design | Eyes at latest follow-up (n) | Age (years) (mean±SD) (Range) | Latest follow-up (months) | UDVA change (logMAR) | CDVA change (logMAR) | MSE change (D) | Cylinder change (D) | K max change (D) | Pachymetry change (microns) | Failure | Retreatment (%) | DALK (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caporossi A72 | 2013 | CS | 26 | 22 (11–26 years) | 24 | 0.08 | 0 | 0 | 0 | 1.55 | −32 | — | — | — |
| Filippello M29 | 2012 | CS | 20 | 27 (12–42 years) | 18 | −0.23 | −0.11 | — | — | −1.17 | −4.00 | 0 | — | — |
| Koppen C27 | 2012 | CS | 37 | 24.02± 7.29 (12–46 years) | 12 | — | −0.04 | +0.21 | +0.04 | 1.33 | −8.06 | — | — | — |
| Leccisotti A30 | 2010 | CS | 51 | 26.9±6.3 (18–39 years) | 12 | — | −0.04 | +0.36 | 0.51 | — | — | — | — | |
| Mastropasqua L36 | 2013 | RCT (ER vs TE) | 20 | 23±2.5 (16–23 years) | 12 | — | — | — | — | — | 0.51 | — | — | — |
| Stojanovic A28 | 2012 | CS | 61 | 32±10 (15–52 years) | 12 | −0.30 | −0.12 | +0.74 | −1.15 | −0.57 | +9.00 | — | — | — |
Abbreviations: CDVA, corrected distance visual acuity; CS, case series; DALK, deep anterior lamellar keratoplasty; ER, epithelial removal; K, keratometry; MSE, mean spherical equivalent; RCT, randomised controlled trial; SD, standard deviation; TR, transepithelial removal; UDVA, uncorrected visual acuity.