Table 1. Gelatinase activity in peripheral samples of Bruch's choroid in control and AMD donors.
| MMP species | Donor group | Free | Bound | Total | |
|---|---|---|---|---|---|
| HMW2 | Control | 1435±1520 | 12 702±3940 | 14 137±4725 | High bad |
| AMD | 6685±5444* | 15 195±3018 | 21 880±8182* | Low good | |
| HMW1 | Control | 1335±2470 | 5996±2911 | 7331±4040 | |
| AMD | 6327±7064** | 10 480±5616 | 16 807±11 950* | ||
| Pro-MMP-9 | Control | 9354±11 895 | 16 068±7692 | 25 422±16 553 | |
| AMD | 33 375±25 579*** | 22 572±7274 | 55 947±30 662* | ||
| Pro-MMP-2 | Control | 1567±1753 | 1393±964 | 2960±2071 | |
| AMD | 379±374* | 674±700 | 1053±854* | ||
| Active MMP-9 | Control | NDet | 517±376 | 517±376 | High good |
| AMD | 195±80* | 195±80* | Low bad | ||
| Active MMP-2 | Control | 357±428 | 1978±1140 | 2336±1257 | |
| AMD | 335±519 | 614±534*** | 949±885* |
*P<0.05.
**P<0.01.
***P<0.005.
This table demonstrates the effect of sequestration of MMPs into high-molecular-weight complexes as a function of age and disease. In AMD, the species of high-molecular-weight are significantly elevated above those of controls. By contrast, active MMPs 2 and 9 are significantly reduced when compared with controls. Bold highlights good vs bad.