Table 2.

μCT results showing cortical and trabecular bone parameter in Wt, Mecp2^stop/y and Mecp2^stop/y, CreER.

Trabecular bone parameters				Cortical bone parameters
Trabecular bone parameters	Wild-type	Mecp2stop/y	Mecp2stop/y, CreER	Cortical bone parameters	Wild-type	Mecp2stop/y	Mecp2stop/y, CreER
Bone volume fraction%	12.35 ± 5.75	11.13 ± 4.67	16.99 ± 8.92	Outer perimeter (mm)	1.65 ± 0.22	1.32 ± 0.07⁎, a	1.38 ± 0.05⁎, c
Bone mineral density g/cm3	0.96 ± 0.07	0.93 ± 0.068	0.94 ± 0.60	Inner perimeter (mm)	1.26 ± 0.08	1.12 ± 0.07⁎, a	1.08 ± 0.05⁎⁎, c
Bone surface density mm2/mm3	8.15 ± 3.05	8.93 ± 3.11	11.29 ± 5.99	Cortical thickness (mm)	0.41 ± 0.17	0.19 ± 0.07⁎, a	0.21 ± 0.08⁎, c
Specific bone surface mm2/mm3	70.25 ± 12.73	78.10 ± 17.92	66.14 ± 9.90	Marrow area (mm2)	0.48 ± 0.14	0.30 ± 0.02⁎⁎, a	0.29 ± 0.03⁎⁎, c
Connectivity density 1/mm3	215.90 ± 93.80	180.90 ± 47.80	271.60 ± 111.25	Cortical area (mm2)	0.81 ± 0.08	0.75 ± 0.13	0.69 ± 0.04
Structure model index	1.03 ± 0.56	0.72 ± 0.67	1.00 ± 0.48	Total area (mm2)	1.26 ± 0.17	1.05 ± 0.11⁎, a	0.98 ± 1.04⁎⁎, c
Trabecular number 1/mm	1.65 ± 0.52	2.12 ± 0.63	1.81 ± 0.72	Bone volume (mm3)	1.75 ± 0.21	1.39 ± 0.19⁎, a	1.39 ± 0.11⁎, c
Trabecular thickness mm	0.07 ± 0.02	0.05 ± 0.02⁎, a	0.09 ± 0.02⁎⁎, b
Trabecular separation mm	0.62 ± 0.36	0.48 ± 0.26	0.14 ± 0.31
Degree of anisotropy	2.63 ± 1.31	2.95 ± 0.88	2.46 ± 0.59
Mean intercept length	0.15 ± 0.04	0.11 ± 0.03	0.32 ± 0.35

Summary table showing μCT analysis of cortical (tibia midshaft) and trabecular (body of 5th lumbar vertebrae) bone. All data given as mean ± S.D. for each group of samples (n ≥ 5 per genotype). Significance was assessed by one way ANOVA with Tukey's post hoc test.

^⁎p < 0.05.

^⁎⁎p < 0.01.

^aComparison between Wt and Mecp2^stop/y.

^bComparison between Mecp2^stop/y and Mecp2^stop/y, CreER.

^cComparison between Wt and Mecp2^stop/y, CreER.