Fig. 2. Comparison of wrinkle area of SKH-1 hairless mice skin applied with test compounds for 4 wks. Values represent the mean ± SD of 7 mice. ^a,b,cValues with different superscripts are significantly different (p < 0.001) by ANOVA and Duncan’s multiple range test. A significant decrease in wrinkle area was observed in RA and CSWE groups.