Fig. 4. Comparison in MMP-3 mRNA expression of SKH-1 hairless mice applied with test compounds for 4 wks. (A) MMP-3 transcript levels decreased by treatment with RA and CSWEs compared to UVB-irradiated control group, as determined by RT-PCR. Expression was normalized to GAPDH levels. (B) Quantification of MMP-3 transcript expression in mice treated with saline (N), UVB radiation (C), 0.01% retinoic acid (RA 0.01%), 2% green tea (GT 2%), 2% white tea (WT 2%), or 2% black tea (BT 2%). Values represent the mean ± SD of 5 mice. a,b,c,dValues with different superscripts are significantly different (p < 0.001) by ANOVA and Duncan’s multiple range test. A significant decrease in MMP-3 mRNA expression was observed in RA and CSWE groups compared to UVB-irradiated control group.
