Fig. 8. Change of IGF-1 expression in C57BL/6 mice. The back skins of the mice were shaved and test compounds were topically applied for 4 wks. Values are the mean ± SD of 3, 3, and 5 mice at week 1, 2, and 4, respectively. The value is significantly different from SA group (^*; p< 0.05; ^**; p< 0.01, ^***; p< 0.001) and JO group (^#; p< 0.05; ^##; p< 0.01) by Student’s t-test. SA; saline, JO; jojoba oil, MXD; 3% minoxidil, PEO; 3% peppermint oil.