Figure 1.

LPS impairs spatial memory in WT but not in Fat-1 mice. Spatial memory was assessed in the Y-maze paradigm for Fat-1 mice and WT littermates. (a) Time spent (in seconds) in the novel or the familiar arm after a 30-min ITI. Only WT mice injected with LPS exhibited a random exploration of the two arms. (b) Time spent (in sec) in the novel or the familiar arm after a 5-min ITI. All the mice spent more time in the novel arm. Data are expressed as mean±SEM. *p<0.05, **p<0.01.