Figure 1.

Reduced dorsal and ventral striatal activations during gain and loss anticipation (A2 phase of the MID task). Whole-brain, task-related activations (k>50; p<0.001, uncorrected) across all participants are shown in coronal slices. Dorsal and ventral ROIs are shown in red (dorsal) and blue (ventral), and average peak activations are plotted for HC and BD II/NOS groups. Group-level random-effects models were conducted using the small-volume correction (SVC) tool in SPM8, and p-values were thresholded using family-wise error correction (pFWE<0.05). These analyses indicated significantly decreased activity among BD II/NOS participants (vs controls) in the dorsal striatum during win anticipation, and within both the dorsal and ventral striatum during loss anticipation. BD, bipolar II or not-otherwise-specified disorder; HC, healthy control.