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Structure activity relationship and binding interaction of mGlu5 (metabotropic glutamate receptor subtype 5) positive allosteric modulators (PAMs). VU0092273 and VU0360172 are mGlu5 PAMs and closely related structural analogs of the prototypical mGlu5 negative allosteric modulator (NAM), MPEP (methyl-6-(phenylethynyl)pyridine hydrochloride), and the mGlu5 NAM PET ligand [18F]FPEB. VU0409106 is structurally distinct from both mGlu5 PAM and NAMs.
