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. 2014 Oct 29;40(3):766–773. doi: 10.1038/npp.2014.256

Figure 2.

Figure 2

Escitalopram effect on GFP-Gαs diffusion is both dose- and time-dependent. (a) C6 cells stably expressing GFP-Gαs were cultured for 3 days at various doses of escitalopram before imaging. (b) C6 cells stably expressing GFP-Gαs were cultured for 3 days with escitalopram treatment (10 μM) initiated in the final 1, 24, 48, or 72 h of culture before imaging. FRAP was performed on 3–6 cells per dish and the half-time to recovery was calculated using a one-phase association fit. Data were analyzed by one-way ANOVA followed by Tukey's test for post hoc multiple comparisons of means (control versus treatment, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001). Error bars represent SEM.