Figure 2.

SA improved glucose tolerance in diabetic db/db mice. Diabetic db/db mice were orally intubated with SA (10 mg kg⁻¹ body weight/day) or PBS. (a) Four weeks and (b) 8 weeks later, mice were not fed for 4 h and were injected with glucose, and blood glucose levels were measured (n = 5–10 per group). The area under the curve measured at (c) 4 weeks and (d) 8 weeks. Untreated diabetic db/db mice and pair-fed diabetic db/db mice served as controls. ^* P < 0.05, ^** P < 0.01, and ^*** P < 0.0001 compared with PBS-treated mice; ^# P < 0.05, ^## P < 0.01, and ^### P < 0.005 compared with the pair-fed group;  ^† P < 0.05 pair-fed mice compared with PBS-treated mice; ^§ P < 0.01, compared with untreated mice.