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. 2014 Dec 11;15(12):549. doi: 10.1186/s13059-014-0549-1

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© Weber et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Ancestral population size predicts descendant GC3. Reconstructed population sizes for internal branches with two descendant lineages are positively correlated with descendant GC3 content. Population size was inferred from relationships between ancestral generation time, split dates, and coalescent branch lengths computed from the degree of gene tree discordance. Note that the population sizes here are expected to be overestimates, as age of first female sexual maturity was used as a proxy for generation time (see Materials and Methods), and are intended to be interpreted in terms of rank order.