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. 2014 Dec 15;2014(1):24. doi: 10.1186/1687-9856-2014-24

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© Arya et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Functional characterisation of K _ATP channels with a heterozygous ABCC8 R526C/H627Mfs*20 compound mutation. A, Representative whole-cell time-current density traces at +40 mV recorded from HEK293 cells expressing Kir6.2/SUR1, Kir6.2/SUR1c1879delC, Kir6.2/SUR1R526C and Kir6.2/SUR1R526C + SUR1C1879delC showing the effects of diazoxide (DZX) and tolbutamide (in the presence of diazoxide) (TOL). Current were recorded using a 1 s ramp protocol (-150 mV to 50 mV). B, Summary of the mean current-densities at +40 mV. Values are mean ± S.E.M from 5–7 cells, *P < 0.05, **P < 0.01 compared to control