[Table/Fig-1]:

Classes of mutation based on their functional role along with the types of mutations

Class	Consequense of Mutation	Type of Mutation
I	No CFTR synthesis	Nonsense; Frameshift; Canonical splice
II	Failure of CFTR to traffic to the cell surface	Missense; Aminoacid deletion
III	Failure of CFTR to open at the cell surface	Missense; Aminoacid change
IV	Decrement in time, the CFTR channel is open at the cell surface	Missense; Aminoacid change
V	Decreased amount of CFTR at the cell surface	Splicing defect; Missense
VI	Unstable CFTR with decreased half-life at the cell surface	Missense; Aminoacid change

Abbreviation: CFTR- CF transmembrane conductance regulator protein