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. 2014 Dec 29;5(6):144. doi: 10.1186/scrt534

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© Boerckel et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Microcomputed tomography angiography analysis of hindlimb ischemia recovery. (A) Three-dimensional reconstructions of distal hindlimb vasculature in wild-type (WT) (left) and MKP-1 knockout (KO) (right) mice at day 7 post-surgery. Reproduced with permission from the American Heart Association [71]. (B) Quantification of vascular volume ratio (ischemic/contralateral control), illustrating the biphasic nature of angiogenic and arteriogenic vascular recovery. Initial conditions (T₀) taken from comparable WT C57Bl6 mice in [75], with continuity indicated by gray lines. Horizontal line illustrates ischemic/control ratio of 1.