Table 2.
Summary of the secondary outcomes implemented in Executive B across all time points
| Visit 1 (baseline) | Visit 2 (6 months) | |
|---|---|---|
| Screening | Medical history (ie demographic screen, medication use) | Medical history (ie medication use) |
| Biochemical | MBA & CRP | MBA & CRP |
| Homocysteine | Homocysteine | |
| B Vitamins (B6, B12) | B Vitamins (B6, B12) | |
| Folate | Folate | |
| COMT | COMT | |
| SLC6A4 | SLC6A4 | |
| FKBP5 | FKBP5 | |
| NPY | NPY | |
| ADCYAP1R1 | ADCYAP1R1 | |
| MTHFR | MTHFR | |
| CPS1 | CPS1 | |
| CBS and DPEP1 | CBS and DPEP1 | |
| Health | FFQ | FFQ |
| BDI-II | BDI-II | |
| POMS | POMS | |
| GHQ | GHQ | |
| PSS | PSS | |
| Cardiovascular | Brachial BP | Brachial BP |
| Aortic BP | Aortic BP | |
| Carotid-femoral PWV | Carotid-femoral PWV | |
| Neuroimaging | Structural MRI | Structural MRI |
| Default mode network activation | Default mode network activation | |
| Metabolite scan (MRS) | Metabolite scan (MRS) | |
| N-Back working memory (functional MRI) | N-Back working memory (functional MRI) | |
| Other | NEO PI-R | Estimate of compliance |
| WASI |
COMT = Catechol-O-methyltransferase gene, SLC6A4 = Serotonin-transporter gene-linked polymorphic region, FKBP5 = Glucocorticoid receptor-regulating co-chaperone of stress proteins, NPY = Neuropeptide Y, ADCYAP1R1 = Pituitary adenylate cyclase-activating polypeptide receptor, MTHFR = Methylenetetrahydrofolate reductase, CPSI = Carbamoyl phosphate synthetase 1, CBS and DPEP1 = Cystathionine –β-synthase and Dipeptidase 1, FFQ = Food Frequency Questionnaire, BDI-II = Beck Depression Inventory II, POMS = Profile of Mood States, GHQ = General Health Questionnaire, PSS = Perceived Stress Scale, NEO PI-R = NEO-Personality Inventory Revised, WASI = Wechsler Abbreviated Scale of Intelligence.