Figure 2.

Development of freezing bouts in J mice during NAL training predicts NAL-CPA for the NAL-paired side. (A) NAL-trained J mice, but not NAL-trained NJ mice (black bars) demonstrated a significant instatement of NAL-induced freezing bouts from the first to second training trial relative to SAL-trained J mice (white bars). (B,C) This behavior predicted the strain-dependent enhancement of drug-free and state-dependent NAL-CPA. ^*Significantly different from SAL control mice (p < 0.0125; Bonferroni-corrected significance threshold). ^#Significantly different from NAL-trained NJ mice (p < 0.0125). Data are presented as the mean ± S.E.M.