Table 1.
Cancer disease association with genes selected in the present study based on Gendoo server.
| Gene Symbol | RefSeq mRNA | Cancer associations (P-value) |
|---|---|---|
| PC2 vs PC2 | ||
| SLC22A3 | NM_021977 | Gonadoblastoma (0.0002), Dysgerminoma (0.00075), Testicular Neoplasms (0.00456), Ovarian Neoplasms (0.0297), Cell Transformation, Neoplastic (0.0384) |
| DFNA5 | NM_004403 | Melanoma (0.006), |
| SPG20 | NM_015087 | Hepatoblastoma (0.0033), Liver Neoplasms (0.00496) |
| CYP1B1 | NM_000104 | Breast Neoplasms (1.13 × 10-45), Endometrial Neoplasms (2.44 × 10-12), Lung Neoplasms (1.56 × 10-9), Prostatic Neoplasms (4.65e-9), Adenocarcinoma (6.03 × 10-6), Ovarian Neoplasms (1.35 × 10-5) Carcinoma, Squamous Cell (0.00018), Colorectal Neoplasms (0.000337), Head and Neck Neoplasms (0.00052), Adenoma, Liver Cell (0.0072), Urinary Bladder Neoplasms (0.012), Neoplasms (0.019), Carcinoma, Small Cell (0.028), Carcinoma, Non-Small-Cell Lung (0.0326) |
| ALX1 | NM_006982 | Carcinoma (0.000305), Chondrosarcoma (0.00129), Bone Neoplasms (0.0106), Uterine Cervical Neoplasms (0.011) |
| TFPI2 | NM006528 | Uterine Neoplasms (2.6 × 10-21), Neoplasm Invasiveness (1.18 × 10-14), Choriocarcinoma (2.33 × 10-13), Fibrosarcoma (7.98 × 10-9), Glioma (2.50 × 10-8), Cystadenocarcinoma (1.68 × 10-5), Lung Neoplasms (6.74 × 10-5), Carcinoma, Non-Small-Cell Lung (0.00559) |
| HOXA9 | NM_152739 | Leukemia, Myeloid (2.0 × 10-48), Leukemia, Myeloid, Acute (9.24 × 10-30), Cell Transformation, Neoplastic (4.64 × 10-29), Leukemia (9.46 × 10-19), Leukemia, Myelogenous, Chronic, BCR-ABL Positive (2.64 × 10-14), Precursor Cell Lymphoblastic Leukemia-Lymphoma (2.46 × 10-8), Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (1.65 × 10-6), Myoma (0.00046), Leukemia, T-Cell (0.0012), Endodermal Sinus Tumor (0.0079), Seminoma (0.0157), |
| HOXA11 | NM_005523 | Uterine Neoplasms (8.23 × 10-7), Choriocarcinoma (3.97 × 10-5), Carcinoma, Endometrioid (0.0065), Adenocarcinoma, Clear Cell (0.00662), Wilms Tumor (0.0076), |
| PCSK1 | NM000439 | Bronchial Neoplasms (0.0022), Adenoma (0.0030), Adenoma, Islet Cell (0.0035), Bile Duct Neoplasms (0.011) |
| SPARC | NM_003118 | Neoplasm Invasiveness (8.42 × 10-14), Glioma (1.35 × 10-8), Brain Neoplasms (1.01 × 10-7), Melanoma (2.99 × 10-7), Lung Neoplasms (1.43 × 10-5), Carcinoma (0.00013), Carcinoma, Non-Small-Cell Lung (0.0009) |
| PC3 vs PC3 | ||
| HOXB2 | NM_002145 | Lung Neoplasms (0.000159), Leukemia, Myeloid (0.000326), Pulmonary Emphysema (0.00139), Carcinoma, Embryonal (0.0025), Adenocarcinoma (0.0054), Leukemia, Erythroblastic, Acute (0.0096), Leukemia, Promyelocytic, Acute (0.0124), Carcinoma, Small Cell (0.0148), Carcinoma, Non-Small-Cell Lung (0.0387) |
| CCDC8 | NM_032040 | |
| ZNF114 | NM_153608 | |
| DIO2 | NM_000793 | Choriocarcinoma (0.000616), Carcinoma, Papillary (0.00366), Hemangioma (0.0099), Adenoma (0.019), Neuroblastoma (0.025) |
| LAPTM5 | NM_006762 | Carcinoma, Hepatocellular (0.000396), Liver Neoplasms (0.000495), Multiple Myeloma (0.00947), Neoplasm Recurrence (0.010), Cell Transformation, Neoplastic (0.032) |
| RGS1 | NM_002922 | Burkitt Lymphoma (3.55 × 10-5), Lymphoma, B-Cell (9.14 × 10-5), Leukemia-Lymphoma, Adult T-Cell (0.0076), Lymphatic Metastasis (0.0329), Skin Neoplasms (0.0364), Stomach Neoplasms (0.0454), Melanoma (0.0455) |
| B3GALNT1 | NM_003781 | Neuroblastoma (0.0034) |
| PC5 vs PC4 | ||
| TINAGL1 | NM_022164 | Carcinoma, Hepatocellular (0.000119), Neoplasms (0.0295) |
| PMEPA1 | NM_020182 | Prostatic Neoplasms (2.30e-12), Carcinoma, Renal Cell (0.0233), Kidney Neoplasms (0.032) |
| CX3CL1 | NM_002996 | Neuroblastoma (0.0014) |
| ICAM1 | NM_000201 | Melanoma (0.00305), astrocytoma (0.00644), Granular Cell Tumor (0.0166), Colonic Neoplasms (0.0233), Lymphoma, AIDS-Related (0.023), Adenoma, Oxyphilic (0.0433) |