Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Dec 8;15(Suppl 9):S3. doi: 10.1186/1471-2164-15-S9-S3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Tyagi et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

(a) Depiction of the complete Bos taurus tubulin assembly comprising chains A, B, C, D and E of which A and C belong to the α chain (shown in orange); B and D belong to the β chain (shown in yellow). The modelled human tubulin β-chain has been compared (in red) and the ligand is shown in blue bound at the α-β interfacial colchicine binding site. (b) Depiction of the binding modes of HPI (in blue) and MSI (in green) compared to the most active arylthioindole derivative (in red) taken as the reference compound and important residues (in cyan).