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. 2014 Dec 8;15(Suppl 9):S6. doi: 10.1186/1471-2164-15-S9-S6

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Copyright © 2014 Huang et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The analytical flow discovering candidate genes and pathways. By analysis of NGS data from BA22 STG sample, the significant differential genes were screened by Bowtie 1 and RSEM to construct the QQPPI network for schizophrenia. The potential complexes or pathways which were searched against pathway and protein complex databases such as NCI-PID, Reactome, Cell-Map, HumanCyc and CORUM are obtained by MCL cluster with the corresponding bioinformatic tools. The right part shows the corresponding analytical tools for the analysis of candidate PPI subnetworks and pathways.