FIG. 3.

Advanced functionality: viral nucleic acid detection using on-chip solid-phase extraction and detection. (a) Solid phase nucleic acid pull-down assay—(I) prepared “pull-down” magnetic beads and (II) nucleic acid target are mixed on automaton (III); washed magnetic particles are sent to the ARROW chip (IV). Particle detection for (b) negative (pull-down non-cognate)—see I—and (c) positive (pull-down cognate) nucleic acid samples—see IV. Single bead signals are marked by arrows in the figure inset.