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. 2014 Dec 8;8(Suppl 4):S4. doi: 10.1186/1752-0509-8-S4-S4

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Copyright © 2014 Moriya et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The effect of downstream genes on regulatory genes in synthetic genetic circuits. (a) Synthetic genetic circuits in a cell. Regulatory genes of synthetic genetic circuits have an effect on downstream genes, such as reporter genes or genes in natural genetic circuits. (b) Competition for regulatory-protein-binding sites among genes encoding regulatory proteins and an additional reporter gene in synthetic genetic circuits. (c) Protein degradation systems in a cell. Proteins often share the same degradation system.