Table 2.

Cannabinoid receptor-independent molecular targets for the putative eCB receptor antagonists

Putative antagonists of eCB receptor	Targets or CB receptor-independent effects	Reference
SR141716A	Antagonizes endothelium-dependent relaxation to carbachol, bradykinin, ionomycin and A23187	Wagner et al., 1999 Randall et al., 1996 White and Hiley, 1997
SR141716A	Antagonizes endothelium-independent relaxation to anandamide	Randall et al., 1996 Harris et al., 2002 Ho and Hiley, 2003a
SR141716A	Inhibition of myoendothelial communications	Chaytor et al., 1999
SR141716A	Inhibits unidentified K+ channels	Bukoski et al., 2002
SR141716A	Inhibits relaxation induced by Ca2+-re-addition	Bukoski et al., 2002
O-1918	Inhibits relaxation of denuded arteries to sodium nitroprusside Inhibits BKCa channels Inhibits Na+-Ca2+ exchanger	Parmar and Ho, 2010 Godlewski et al., 2009 Bondarenko et al., 2013
Cannabidiol	Acts as PPAR γ ligand Antagonist of α1 adrenoceptors Inhibits voltage-gated Na+ channels Inhibits 5-HT3 receptors Activates TRPV channels	O'Sullivan et al., 2009 Pertwee et al., 2002 Hill et al., 2014 Yang et al., 2010 Hassan et al., 2014

BK_Ca, high-conductance Ca²⁺-dependent K⁺ channels; SR141716, rimonabant.