Table 1.

Subset of AKAP family members known to regulate biological functions in the lung and brain

AKAP	Interactions	Processes involved
AKAP5 (HUGO) AKAP79 (Human) AKAP150 (Murine) AKAP75 (Bovine) H21	AKAP12, AKAP5 β1/β2-adrenoceptor AC5, Epac2 PKB/Akt, PKC PP2A/B, Calcineurin, Calmodulin PSD-95, MAGUK, SAP97 PIP2, F-actin E-/N-Cadherin AMPA/NMDA receptor Cav1.2	β2-AR switching to ERK β2-AR desensitization Cell cycle progression Synaptic plasticity
AKAP12 (HUGO) AKAP250 Gravin (Human) SSeCKS (Murine) Tsga12 Srcs5 AI317366	AKAP5, AKAP12 β2-adrenoceptor PKC	β2-AR resensitization Cell cycle progression Synaptic plasticity
Ezrin AKAP78 Cytovillin p81 Villin-2	EBP50 (NHERF1) GRK2 RhoGDI Rho Rac Epac	β2-AR internalization Actin-binding linker protein

The most important AKAP interactions are highlighted, except of their primary binding partner PKA. Text between parentheses, AKAP synonym using the HUGO gene nomenclature or name of a certain orthologue. For further details and references, see text. β₂-AR, β₂-adrenoceptor.