Figure 5.
Effect of M30 on cerebral MAO-A and -B activities and striatal amine metabolism in HFD mice. (A) MAO-A and -B activities were determined in the cerebellum of mice fed with ND (control) or HFD treated with vehicle or M30 (5 mg⋅kg−1). Results represent MAO activity (% of control); means ± SEM. ND mice served as control. (B) Striatal DA, DOPAC, HVA, 5-HT, 5-HIAA and NA levels were determined via EC-HPLC analysis. Results represent means (pmol·mg−1) ± SEM (n = 7). #P < 0.05 versus ND mice; *P < 0.05 versus vehicle-treated HFD mice.