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Effect of NCX inhibition by ORM10103 on INCX, APD and [Ca2+]i. Using the conventional ramp protocol, 10 μM ORM10103 efficiently inhibited INCX in both transport modes of the exchanger (A). Like SEA0400, ORM10103 also failed to modulate APD90 (B), the amplitude of the [Ca2+]i transient (C) or cell shortening (D).
