Figure 7.

NCX inhibition has no effect on the I_NaL activation-induced APD lengthening. The experimental protocol was identical to that used in Figure 4. In contrast to [Ca²⁺]_i transient measurements, NCX inhibition was ineffective against the I_NaL activation-induced APD₉₀ prolongation. Neither SEA0400 (A, B) nor ORM10103 (C, D) reversed or even substantially decreased the lengthening of APD, leading frequently to generation of EADs. Statistical significances were verified using repeated measure anova plus Bonferroni post hoc test. Columns and bars represent means ± SEM. *Denote significant differences from control, while #from the group pretreated with either SEA0400 or ORM10103 (P < 0.05).