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Estimation of fwdINCX inhibition by 10 μM ORM10103 during Ca2+i load. In the ORM10103-untreated group (A), compared with control, 2 μM forskolin markedly enhanced the ICa and the NCX tail current (C, upper panel). Pretreatment with 10 μM ORM10103 had no apparent effect on the baseline current (the baseline curve is not shown), but 2 μM forskolin still significantly increased both currents (B, C).
