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. 2014 Dec 1;171(24):5682–5695. doi: 10.1111/bph.12870

Figure 4.

Figure 4

Effect of NOS inhibition, endothelium removal and NADPH blockade on the ET-1-induced vasoconstriction of penile arteries. (A, B) Effect of L-NOARG (100 μM) treatment on the contractile response to ET-1 in penile arteries from LZR (A) and OZR (B). (C, D) Average effect of apocynin (30 μM) and endothelium removal in the presence of L-NOARG on the vasoconstriction induced by ET-1 in penile arteries from LZR and OZR. (E, F) Average effects of apocynin (30 μM) on the ET-1-induced contractions in endothelium-denuded (-ENDO) penile arteries from LZR (E) and OZR (F). Results are means ± SEM of n = 3–5 animals (one to two arteries from each animal). †P < 0.05 versus L-NOARG-treated Emax; one-way anova followed by Bonferroni as a posterio test. **P < 0.01 versus -ENDO; Student's t-test for unpaired observations.