Table 2.

Effect of inhibition of NOS (L-NOARG, 100 μM), endothelium removal (-ENDO) and inhibition of NADPH oxidase (apocynin, 30 μM) on the vasoconstriction elicited by ET-1 in penile arteries from LZR and OZR

	ET-1
	LZR			OZR
	pEC50	Emax	n	pEC50	Emax	n
Control	9.22 ± 0.12	138 ± 7	6	9.56 ± 0.18f	142 ± 7	7
+L-NOARG	10.14 ± 0.18b	121 ± 9	5	10.44 ± 0.22a	123 ± 10	5
+L-NOARG -ENDO	8.95 ± 0.15d	150 ± 13	3	8.70 ± 0.18ad	163 ± 9c	4
+L-NOARG + apocynin	8.92 ± 0.25d	141 ± 14	4	8.92 ± 0.14d	119 ± 7	4
Control-ENDO	9.04 ± 0.20a	165 ± 15a	5	8.68 ± 0.16b	203 ± 19b	5
-ENDO + apocynin	8.91 ± 0.16	156 ± 14	4	8.78 ± 0.18	139 ± 7e	4

Values represent mean ± SEM of the number n of animals (one to two individual arteries from each animal were used). Significant differences from controls were analysed by one-way anova followed by Bonferroni as a posterio test or Student's t-test for unpaired observations.

^aP < 0.05;

^bP < 0.01 versus control.

^cP < 0.05;

^dP < 0.01 versus L-NOARG-treated.

^eP < 0.01 versus control-ENDO.

^fP < 0.05 versus LZR.