Figure 6.

4-bromopropofol, but not propofol induced a large strychnine-sensitive tonic conductance. (A) A typical recording demonstrating the change in tonic current caused by strychnine upon 4-bromopropofol (BP) treatment. Note that strychnine not only shifted the baseline of the holding current, but also decreased the current noise. (B) In sham-treated slices, the strychnine-induced change in tonic current was small as compared with the change observed with 4-bromopropofol. (C) Quantification of the effects of strychnine in sham-treated slices and in slices treated either with propofol (PRO) or 4-bromopropofol. Note that the changes observed in sham-treated slices and in propofol-treated slices were almost identical, indicating that propofol did not alter the strychnine-sensitive conductance. **P < 0.01, significantly different from sham; anova. Numbers of experiments are shown as insets in the columns.