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. 2014 Nov 24;171(24):5881–5897. doi: 10.1111/bph.12893

Figure 8.

Figure 8

The concomitant treatment with a low dose of SB203580 and a low dose of fluorocitrate also reduced the development of MA, but had no effect on TH. (A) I.t. injection of SB203580 blocked the increase in response frequency (%) that was observed in vehicle-treated CCI mice in dose-dependent manner. (B) However, the decrease in response latency (s) to heat stimuli was unaffected by repeated i.t. treatment with SB203580. (C, D) The lowest dose of SB203580 had no effect on CCI-induced MA and TH. When a combination of SB203580 and fluorocitrate was given, MA was reduced, compared with the effects shown in either the SB203580 or fluorocitrate alone treated group. TH was not affected by concomitant SB203580 and fluorocitrate treatment. *P < 0.05, **P < 0.01 and ***P < 0.001 as compared with those of CCI + VEH group.