Table 1.
Definition of the clinical endpoints for the 498 SEQC NB samples and the 175 AML samples
Endpoint category | Data set | Total samples(n) | Endpoint | Training set | Validation set | ||||
---|---|---|---|---|---|---|---|---|---|
Samples(n) | 1 | 0 | Samples(n) | 1 | 0 | ||||
Binary (1/0) | SEQC NB | 498 | A_EFS_All (event, yes/no) | 249 | 89 | 160 | 249 | 94 | 155 |
B_OS_All (death, yes/no) | 249 | 51 | 198 | 249 | 54 | 195 | |||
C_SEX_All (female/male) | 249 | 103 | 146 | 249 | 108 | 141 | |||
272 | D_FAV_All (unfavorable/favorable) | 136 | 45 | 91 | 136 | 46 | 90 | ||
176 | E_EFS_HR (event, yes/no) | 86 | 55 | 31 | 90 | 65 | 25 | ||
F_OS_HR (death, yes/no) | 86 | 43 | 43 | 90 | 49 | 41 | |||
AML | 175 | Sex (female/male) | 89 | 43 | 46 | 86 | 39 | 47 | |
Cytogenetic risk (poor/good) | 89 | 72 | 17 | 86 | 70 | 16 | |||
Continuous (time) | SEQC NB | 498 | A_EFS_All (event, days) | 249 | 249 | ||||
B_OS_All (death, days) | 249 | 249 | |||||||
176 | E_EFS_HR (event, days) | 86 | 90 | ||||||
F_OS_HR (death, days) | 86 | 90 | |||||||
AML | 175 | EFS (event, months) | 89 | 86 | |||||
OS (death, months) | 89 | 86 |
EFS: Event-free survival; FAV: Unfavorable/Favorable (class label for extreme disease course); HR: High-risk patients; OS: Overall survival.