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. Author manuscript; available in PMC: 2015 Jan 12.
Published in final edited form as: Cell. 2012 Oct 26;151(3):619–629. doi: 10.1016/j.cell.2012.09.017

Figure 2. Energy Landscape of Dynamin-Mediated Fission.

Figure 2

(A) Mechanism and associated energy landscape for dynamin-mediated fission reaction. Intermediate state corresponds to hemifission, in agreement with experiments using lysolipids shown in Figure S2.

(B) Energy of the neck joining the bare membrane tube with the dynamin-coated tube (blue) and energy of the neck joining a GUV or bead to a dynamin-coated tube (green) as a function of α = Rm/Rc with Rm as the radius of the dynamin-free tube and Rc as the radius of the constricted dynamin-coated tube.

(C) Total energy barrier for fission within the lipid tube (blue) or in the GUV-dynamin or bead-dynamin edge (green) as a function of tension for κ = 16 kBT and Ri = 3nm, Ru = 10 nm.