TABLE 3.
Sensitivity, specificity, positive predictive value, negative predictive value, and ROC area for each of the seven theoretical algorithmsa
| Parameter | Value [% or mean (95% binomial CI)] for algorithm: |
||||||
|---|---|---|---|---|---|---|---|
| A | B | C | D | B′ | C′ | D′ | |
| Sensitivity | 85.47 | 81.82 | 84.36 | 82.68 | 85.47 | 85.47 | 82.68 |
| Specificity | 99.98 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 |
| PPV | 95.03 | 98.69 | 98.69 | 99.33 | 100.00 | 100.00 | 100.00 |
| NPV | 99.95 | 99.94 | 99.94 | 99.94 | 99.95 | 99.94 | 99.94 |
| ROC area | 0.93 (0.93–0.93) | 0.91 (0.91–0.91) | 0.92 (0.92–0.92) | 0.91 (0.91–0.92) | 0.93 (0.93–0.93) | 0.93 (0.93–0.93) | 0.91 (0.91–0.92) |
a
Values are in comparison to the results for the gold standard of HIV-1 viral load. PPV, positive predictive value; NPV, negative predictive value; ROC, receiver operating characteristics.