TABLE 2.
Molecular profiles associated with decreased susceptibility to ceftriaxone
| Molecular marker associated with resistancea |
No. of isolates in the ceftriaxone MIC range groupb | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| penA mosaic |
porB |
mtrR |
ponAL421P | |||||||||
| G120K | A121c | −35A deletion | A39T | G45D | Very low | Low | Moderate | High | Very high | Total | ||
| + | + | + | + | − | − | + | 1 | 25 | 33 | 1 | 60 | |
| + | + | + | + | − | + | + | 2 | 2 | 4 | |||
| + | + | + | − | − | + | + | 2 | 2 | ||||
| + | + | + | − | − | − | + | 1 | 1 | ||||
| + | − | − | + | − | − | + | 3 | 1 | 4 | |||
| − | + | + | + | − | − | + | 2 | 6 | 13 | 21 | ||
| − | + | + | + | − | + | + | 1 | 2 | 6 | 9 | ||
| − | + | + | + | + | + | + | 1 | 1 | ||||
| − | + | + | + | + | − | + | 1 | 1 | ||||
| − | + | + | + | − | − | + | 1 | 1 | ||||
| − | + | + | − | − | + | + | 2 | 2 | ||||
| − | + | + | − | + | − | − | 1 | 1 | ||||
| − | + | + | − | − | + | + | 1 | 1 | ||||
| − | + | + | − | − | − | + | 1 | 1 | ||||
| − | + | + | + | − | − | + | 3 | 3 | ||||
| − | + | + | + | − | − | − | 1 | 1 | ||||
| − | + | + | − | + | − | + | 1 | 1 | ||||
| − | − | + | + | − | − | + | 3 | 2 | 5 | |||
| − | − | − | + | − | − | + | 2 | 1 | 3 | |||
| − | − | + | + | − | + | + | 1 | 1 | ||||
| − | − | + | − | + | − | + | 1 | 1 | ||||
| − | − | + | − | + | − | − | 2 | 1 | 3 | |||
| − | − | − | − | + | − | − | 14 | 6 | 1 | 21 | ||
| − | − | − | − | − | + | + | 3 | 3 | ||||
| − | − | + | − | − | − | − | 9 | 2 | 11 | |||
| − | − | − | − | − | − | − | 16 | 1 | 17 | |||
| Total | 46 | 19 | 47 | 66 | 1 | 179 | ||||||
a
Symbols: +, present; −, absent.
b
MIC range categories for ceftriaxone include the following: very low, 0.00025 to 0.004 μg/ml; low, 0.008 to 0.016 μg/ml; moderate, 0.032 to 0.063 μg/ml; high, 0.125 to 0.5 μg/ml; very high, 1 to 2 μg/ml.
c
porB A121 substitutions include A121D, A121F, A121G, A121N, and A121G.