TABLE 3.
hla genotypes associated with S. aureus bacteremia among hemodialysis and postsurgery patients
| hla genotype | n | Amino acid residue or codon found at positiona: |
Neutralized by MEDI4893 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| V6 | I40 | L78 | Q113 | T155 | D234 | S265 | D272 | H285 | T294 | I301 | S304 | K314 | |||
| 1 (USA300) | 32 | V | I | L | Q | T | D | S | D | H | T | I | S | K | Yes |
| 2 | 114 | E | T | Yes | |||||||||||
| 3 | 21 | I | Stop | S | E | T | T | NTb | |||||||
| 4 | 11 | T | Yes | ||||||||||||
| 5 | 7 | I | S | T | T | Yes | |||||||||
| 6 | 4 | E | Yes | ||||||||||||
| 7 | 3 | F | T | Yes | |||||||||||
| 8 | 1 | A | I | S | E | T | N | T | Yes | ||||||
| 9 | 1 | I | S | T | N | T | Yes | ||||||||
| 10 | 1 | I | S | T | T | C | Yes | ||||||||
| 11 | 1 | I | S | Y | T | Yes | |||||||||
| 12 | 1 | E | T | N | Yes | ||||||||||
| Total | 197c | 1 | 3 | 32 | 21 | 32 | 141 | 31 | 1 | 1 | 1 | 161 | 1 | 1 | |
a
The amino acid numbering system employed starts at the first methionine and includes the whole open reading frame.
b
NT, not tested. Isolates with a stop codon at Q113 did not produce alpha-toxin and were not tested in the toxin neutralization assay.
c
Of the 200 isolates, 197 had a detectable hla gene.