TABLE 1.
Details of the diagnostic criteria for various clinical presentations of aspergillosis included in the study
| Groupa | Criteria |
|---|---|
| Aspergillus disease | |
| CPA | (i) Abnormal radiological/CT scan images |
| (ii) Alteration of the patient's general state | |
| (iii) Aspergillus sp.-positive culture (±3 mo) from respiratory sample or biopsy specimen and/or Aspergillus fumigatus precipitin IgG | |
| Aspergilloma | (i) Radiological/CT scan Monad's sign |
| (ii) No deterioration of the patient's general state | |
| (iii) Aspergillus sp.-positive culture (±3 mo) from respiratory sample or biopsy specimen and/or Aspergillus fumigatus precipitin IgG | |
| ABPAb | (i) Degradation of respiratory functions |
| (ii) Global IgE level of ≥1,000 kIU/liter | |
| (iii) Aspergillus-specific IgE level of ≥0.7 kIU/liter | |
| (iv) Global IgE level of ≥500 kIU/liter | |
| (v) Aspergillus sp.-positive culture (±3 mo) and/or Aspergillus fumigatus precipitin IgG and/or an abnormal radiological status | |
| Colonization | |
| Aspergillus colonization | (i) Two Aspergillus sp.-positive cultures from respiratory samples collected between ≥10 days apart and ≤6 mo apart |
| (ii) No Aspergillus disease criterion | |
| Control | |
| Blood donors | Randomly selected blood donor sera |
The Aspergillus disease and Aspergillus colonization groups are included in the aspergillosis sensu lato group. CPA, chronic pulmonary aspergillosis; ABPA, allergic bronchopulmonary aspergillosis; CT, computed tomography.
Criteria i, ii, and iii or i, iii, iv, and v are mandatory.