TABLE 2.
In vitro susceptibilities of 187 isolates of Candida spp. to caspofungin, anidulafungin, and micafungina
| Species (no. of isolates tested) | Antifungal agent | Test method | MIC (μg/ml) |
EA (%) | CA (%) | % errors |
|||
|---|---|---|---|---|---|---|---|---|---|
| Range | Mode | VME | ME | Minor errors | |||||
| C. albicans (120) | Caspofungin | BMD | 0.016–0.5 | 0.016 | |||||
| Caspofungin | MIC test strip | 0.032–0.5 | 0.094 | 49.2 | 99.2 | 0 | 0 | 0.8 | |
| Caspofungin | SensiQuattro | <0.03–>0.25 | 0.06 | 60.3 | ND | ND | ND | ND | |
| Anidulafungin | BMD | 0.016–4 | 0.016 | ||||||
| Anidulafungin | MIC test strip | <0.002–>32 | >32 | 0 | 95.8 | 2.5 | 0 | 1.7 | |
| Anidulafungin | SensiQuattro | 0.015–>0.12 | 0.12 | 32.8 | 14.7 | 0.8 | 82.8 | 1.7 | |
| Micafungin | BMD | 0.016–2 | 0.016 | ||||||
| Micafungin | MIC test strip | 0.002–0.094 | 0.012 | 92.5 | 68.3 | 24.2 | 7.5 | 0 | |
| Micafungin | SensiQuattro | <0.03–>0.25 | 0.12 | 46.6 | 29.4 | 3.4 | 67.2 | 0 | |
| C. glabrata (38) | Caspofungin | BMD | 0.016–0.12 | 0.03 | |||||
| Caspofungin | MIC test strip | 0.064–0.25 | 0.19 | 85 | 42.1 | 0 | 0 | 55 | |
| Caspofungin | SensiQuattro | <0.03–>0.25 | 0.12 | 68.4 | ND | ND | ND | ND | |
| Anidulafungin | BMD | 0.03–0.25 | 0.06 | ||||||
| Anidulafungin | MIC test strip | <0.002–0.032 | 0.016 | 0 | 100 | 0 | 0 | 0 | |
| Anidulafungin | SensiQuattro | <0.015–>0.12 | >0.25 | 76.3 | 42.1 | 0 | 57.9 | 0 | |
| Micafungin | BMD | 0.016–0.03 | 0.016 | ||||||
| Micafungin | MIC test strip | 0.002–0.032 | 0.008 | 55 | 100 | 0 | 0 | 0 | |
| Micafungin | SensiQuattro | <0.03–>0.25 | >0.25 | 44.7 | 26.3 | 0 | 73.7 | 0 | |
| C. parapsilosis (10) | Caspofungin | BMD | 0.25–1 | 0.5 | |||||
| Caspofungin | MIC test strip | 0.19–2 | 0.38 | 100 | 40 | 2 | 0 | 4 | |
| Caspofungin | SensiQuattro | <0.03–>0.25 | >0.25 | 90 | ND | ND | ND | ND | |
| Anidulafungin | BMD | 2–4 | 2 | ||||||
| Anidulafungin | MIC test strip | 2–>32 | >32 | 30 | 30 | 0 | 0 | 70 | |
| Anidulafungin | SensiQuattro | <0.015–0.12 | 0.015 | 0 | 100 | 0 | 0 | 0 | |
| Micafungin | BMD | 1–4 | 1 | ||||||
| Micafungin | MIC test strip | 0.006–0.016 | 0.008 | 0 | 90 | 0 | 0 | 10 | |
| Micafungin | SensiQuattro | <0.03–0.12 | <0.03 | 0 | ND | ND | ND | ND | |
| C. tropicalis (12) | Caspofungin | BMD | 0.016–0.12 | 0.12 | |||||
| Caspofungin | MIC test strip | 0.064–0.5 | 0.19 | 75 | 91.7 | 0 | 0 | 8.3 | |
| Caspofungin | SensiQuattro | <0.03–>0.25 | >0.25 | 50 | ND | ND | ND | ND | |
| Anidulafungin | BMD | 0.016–0.12 | 0.03 | ||||||
| Anidulafungin | MIC test strip | <0.002–0.002 | <0.002 | 0 | 91.7 | 8.3 | 0 | 0 | |
| Anidulafungin | SensiQuattro | 0.03–>0.25 | >0.12 | 41.6 | 25 | 0 | 75 | 0 | |
| Micafungin | BMD | 0.016–0.06 | 0.03 | ||||||
| Micafungin | MIC test strip | 0.003–>32 | 0.006 | 25 | 75 | 0 | 25 | 0 | |
| Micafungin | SensiQuattro | 0.03–>0.25 | >0.25 | 50 | ND | ND | ND | ND | |
| C. krusei (7) | Caspofungin | BMD | 0.016–8 | 0.06 | |||||
| Caspofungin | MIC test strip | 0.19–>32 | 0.75 | 30 | 42.9 | 0 | 0 | 57.1 | |
| Caspofungin | SensiQuattro | <0.03–>0.25 | >0.25 | 44.4 | ND | ND | ND | ND | |
| Anidulafungin | BMD | 0.016–4 | 0.06 | ||||||
| Anidulafungin | MIC test strip | <0.002–>32 | <0.002 | 0 | 85.7 | 14.3 | 0 | 0 | |
| Anidulafungin | SensiQuattro | <0.015–>0.12 | >0.12 | 66.6 | 28.7 | 14.2 | 57.1 | 0 | |
| Micafungin | BMD | 0.03–>8 | 0.12 | ||||||
| Micafungin | MIC test strip | 0.004–3 | 3 | 0 | 0 | 10 | 80 | 10 | |
| Micafungin | SensiQuattro | <0.03–>0.25 | >0.25 | 22.2 | ND | ND | ND | ND | |
a
As determined with the SensiQuattro Candida EU (SQ), the EUCAST broth microdilution (BMD) protocol, and the MIC test strip. EA, essential agreement; CA, categorical agreement; VME, very major error; ME, major error. ND, nondeterminable: measurements of MIC cannot differentiate between susceptible, intermediate, or resistant.