TABLE 2.
Concentrations of Sertraline and N-Desmethyl Sertraline in Ms. A and Her Baby Compared to Those in Published Data
| Time and Group | Concentrations in Ms. A and Her Baby (ng/ml) | Concentrations in Published Data (ng/ml)a
|
|
|---|---|---|---|
| Mean | SD | ||
| 30 weeks’ gestation | |||
| Maternal sertraline | 26.3 | ||
| Maternal N-desmethyl sertraline | 43.7 | ||
| Birth | |||
| Maternal sertraline | 11.2 | 5.3 | 3.3 |
| Maternal N-desmethyl sertralinef | 25.9 | 37.8 | 23.0 |
| Cord blood sertraline | 2.7 | — | range=<1.0–2.0 |
| Cord blood N-desmethyl sertraline | 7.9 | 9.8 | 3.9 |
| Ratio of cord blood to maternal sertraline | 0.24 | 0.32 | 0.24 |
| Ratio of cord blood to maternal N-desmethyl sertraline | 0.30 | 0.35 | 0.29 |
| 4 weeks’ postpartum | |||
| Maternal sertraline | 26.9 | ||
| Maternal N-desmethyl sertraline | 51.5 | ||
| Infant sertraline | <1.7 | ||
| Infant N-desmethyl sertraline | 5.3 | ||
a
From Hendrick et al. (15) from four mothers treated with 50 mg/day of sertraline.