Table III.
Associations between subpathway genes and colon cancer for SNPs included in polygenic score (P ARTP < 0.10)
| Subpathway | Gene | Gene P ARTP | SNP | Genotype | SNP P a | OR 95% CIb |
|---|---|---|---|---|---|---|
| Angiogenesis | FLT1 | 0.089 | rs2296189 | AG/GG versus AA | 0.029 | 0.85 (0.74, 0.98) |
| rs3794400 | TT versus CC | 0.012 | 1.36 (0.94, 1.96) | |||
| rs2387632 | TT versus CC/CT | 0.007 | 1.32 (1.08, 1.62) | |||
| rs1324057 | TT versus CC | 0.031 | 1.26 (0.99, 1.60) | |||
| rs7324547 | GA/AA versus GG | 0.033 | 1.16 (1.01, 1.34) | |||
| rs9513088 | GG versus AA | 0.050 | 1.22 (0.99, 1.51) | |||
| rs2296283 | CC versus TT | 0.072 | 1.20 (0.99, 1.45) | |||
| rs12858139 | CA/AA versus CC | 0.010 | 1.21 (1.05, 1.40) | |||
| rs600640 | TC/CC versus TT | 0.041 | 1.15 (1.01, 1.32) | |||
| rs678714 | TA/AA versus TT | 0.020 | 0.82 (0.69, 0.97) | |||
| Hormone/insulin/ growth | SLC2A4 | 0.010 | rs5435 | TT versus CC/CT | 0.001 | 0.73 (0.60, 0.88) |
| TCF7L2 | 0.066 | TCF7L2 | CT/TT versus CC | 0.068 | 1.13 (0.99, 1.30) | |
| VDR | 0.018 | VDR_Fok1 | ff versus FF | 0.005 | 0.75 (0.60, 0.93) | |
| VDR_Poly | SS versus LL | 0.036 | 0.79 (0.65, 0.97) | |||
| Interferons | IFNG | 0.003 | rs2069718 | TT versus CC | 0.070 | 0.84 (0.69, 1.02) |
| rs1861493 | AG/GG versus AA | 0.001 | 0.79 (0.69, 0.91) | |||
| IRF3 | 0.012 | rs2304204 | GG versus AA/AG | 0.004 | 1.43 (1.12, 1.82) | |
| Interleukins | IL15 | 0.061 | rs1519551 | GG versus AA | 0.033 | 0.81 (0.67, 0.99) |
| rs13117878 | TT versus CC | 0.011 | 1.28 (1.06, 1.55) | |||
| IL2RA | 0.095 | rs12244380 | AG/GG versus AA | 0.043 | 1.16 (1.00, 1.34) | |
| rs12722596 | GG versus AA | 0.075 | 1.34 (0.66, 2.69) | |||
| rs12722561 | AA versus GG/GA | 0.004 | 0.49 (0.30, 0.79) | |||
| rs706779 | GG versus AA | 0.062 | 1.19 (0.99, 1.43) | |||
| rs3118470 | TC/CC versus TT | 0.043 | 0.87 (0.76, 1.00) | |||
| IL3 | 0.056 | rs181781 | AA versus GG/GA | 0.025 | 2.42 (1.12, 5.22) | |
| IL6 | 0.095 | rs1800795 | CC versus GG | 0.073 | 0.84 (0.69, 1.03) | |
| rs2069860 | AT/TT versus AA | 0.033 | 0.55 (0.32, 0.95) | |||
| IL6R | 0.033 | rs7549250 | TC/CC versus TT | 0.026 | 0.85 (0.74, 0.98) | |
| rs4845623 | GG versus AA/AG | 0.005 | 1.29 (1.08, 1.53) | |||
| IL8 | 0.027 | rs4073 | AA versus TT | 0.014 | 1.26 (1.04, 1.53) | |
| Jak/Stat/Socs | JAK2 | 0.072 | rs1887429 | GT/TT versus GG | 0.029 | 0.86 (0.75, 0.99) |
| rs3780379 | AA versus GG/GA | 0.007 | 1.68 (1.16, 2.44) | |||
| SOCS2 | 0.057 | rs768775 | TC/CC versus TT | 0.020 | 1.18 (1.03, 1.36) | |
| STAT3 | 0.024 | rs8069645 | AG/GG versus AA | 0.031 | 1.16 (1.01, 1.32) | |
| rs6503695 | CC versus TT | 0.003 | 1.32 (1.07, 1.64) | |||
| rs12949918 | CC versus TT | 0.023 | 1.23 (1.01, 1.49) | |||
| rs1026916 | AA versus GG | 0.064 | 1.20 (0.98, 1.48) | |||
| STAT5A | 0.008 | rs7217728 | CC versus TT | 0.003 | 1.31 (1.04, 1.66) | |
| STAT5B | 0.007 | rs6503691 | TT versus CC | 0.007 | 1.59 (1.00, 2.53) | |
| rs7218653 | GG versus AA | 0.009 | 1.30 (1.03, 1.64) | |||
| STAT6 | 0.095 | rs324015 | GA/AA versus GG | 0.020 | 0.85 (0.74, 0.97) | |
| rs324011 | TT versus CC | 0.087 | 1.20 (0.98, 1.46) | |||
| MAPK | DUSP2 | 0.093 | rs1724120 | AA versus GG/GA | 0.095 | 1.15 (0.98, 1.35) |
| MAP2K1 | 0.043 | rs1432442 | AA versus GG | 0.075 | 0.69 (0.35, 1.38) | |
| rs7181936 | TT versus GG/GT | 0.027 | 1.27 (1.03, 1.58) | |||
| rs8039880 | GG versus AA | 0.007 | 0.57 (0.38, 0.83) | |||
| MAP3K3 | 0.035 | rs11658329 | GC/CC versus GG | 0.035 | 1.16 (1.01, 1.32) | |
| rs3785574 | GG versus AA/AG | 0.031 | 0.79 (0.63, 0.98) | |||
| MAP3K9 | 0.018 | rs11625206 | TT versus CC/CT | 0.002 | 1.41 (1.14, 1.76) | |
| rs11844774 | TC/CC versus TT | 0.008 | 0.83 (0.72, 0.95) | |||
| rs11628333 | CC versus TT/TC | 0.028 | 1.25 (1.02, 1.52) | |||
| rs17176971 | AA versus GG/GA | 0.041 | 1.49 (1.02, 2.20) | |||
| rs11624934 | GG versus AA/AG | 0.002 | 1.42 (1.13, 1.79) | |||
| Pathway core | MTOR | 0.012 | rs1057079 | AG/GG versus AA | 0.006 | 1.21 (1.06, 1.38) |
| rs2024627 | CT/TT versus CC | 0.031 | 1.16 (1.01, 1.33) | |||
| PRKAG2 | 0.072 | rs1029947 | GG versus AA/AG | 0.046 | 1.70 (1.01, 2.87) | |
| rs6464156 | AG/GG versus AA | 0.020 | 0.83 (0.71, 0.97) | |||
| rs953221 | CT/TT versus CC | 0.033 | 0.86 (0.75, 0.99) | |||
| rs9648723 | CC versus AA/AC | 0.013 | 1.51 (1.09, 2.09) | |||
| rs6947064 | GG versus AA | 0.061 | 0.81 (0.66, 1.00) | |||
| rs2374270 | AA versus CC | 0.069 | 0.83 (0.67, 1.03) | |||
| rs1860743 | AA versus GG | 0.018 | 0.65 (0.36, 1.16) | |||
| rs2536068 | AA versus GG | 0.072 | 1.18 (0.84, 1.66) | |||
| rs1104897 | AA versus GG | 0.009 | 1.46 (0.94, 2.26) | |||
| rs6965771 | TT versus CC | 0.090 | 0.89 (0.69, 1.16) | |||
| rs9632641 | CC versus AA | 0.023 | 1.28 (0.92, 1.78) | |||
| rs6464170 | GG versus CC/CG | 0.038 | 0.73 (0.54, 0.98) | |||
| rs9648724 | AA versus GG | 0.022 | 0.74 (0.56, 1.00) | |||
| rs12703162 | CT/TT versus CC | 0.049 | 0.87 (0.75, 1.00) | |||
| RPS6KB2 | 0.010 | rs917570 | CG/GG versus CC | 0.004 | 0.81 (0.70, 0.94) | |
| Telomere | TERT | 0.040 | rs2853668 | AA versus CC | 0.036 | 0.70 (0.54, 0.92) |
| rs2736118 | GG versus AA | 0.048 | 1.31 (1.02, 1.69) | |||
| rs2736100 | GG versus TT/TG | 0.016 | 0.83 (0.71, 0.97) | |||
| TGFβ | BMP2 | 0.002 | rs1979855 | TC/CC versus TT | 0.001 | 1.29 (1.11, 1.48) |
| rs3178250 | TC/CC versus TT | 0.009 | 1.20 (1.05, 1.38) | |||
| rs235770 | TT versus CC | 0.022 | 0.78 (0.63, 0.97) | |||
| BMPR1A | 0.038 | rs6586034 | TG/GG versus TT | 0.010 | 0.82 (0.71, 0.95) | |
| rs7088641 | TC/CC versus TT | 0.006 | 0.83 (0.73, 0.95) | |||
| BMPR1B | 0.017 | rs9307147 | GG versus AA | 0.003 | 0.75 (0.62, 0.91) | |
| rs4490463 | GG versus AA | 0.038 | 0.82 (0.67, 1.00) | |||
| rs17616243 | TT versus CC | 0.006 | 1.45 (0.94, 2.26) | |||
| rs2120834 | CC versus GG/GC | 0.019 | 0.79 (0.65, 0.96) | |||
| rs7662504 | CC versus AA | 0.017 | 0.78 (0.64, 0.96) | |||
| rs7694043 | CT/TT versus CC | 0.095 | 1.12 (0.98, 1.29) | |||
| rs13134042 | AA versus GG | 0.081 | 0.69 (0.49, 0.97) | |||
| rs1863652 | TT versus CC/CT | 0.030 | 0.79 (0.64, 0.98) | |||
| EIF4E | 0.007 | rs12498533 | CC versus AA | 0.013 | 1.25 (1.03, 1.52) | |
| rs11727086 | GG versus AA | 0.004 | 1.33 (0.99, 1.77) | |||
| RUNX1 | 0.090 | rs2834645 | TC/CC versus TT | 0.006 | 0.82 (0.72, 0.95) | |
| rs2834650 | CT/TT versus CC | 0.066 | 0.85 (0.71, 1.01) | |||
| rs2268281 | GG versus AA | 0.076 | 1.40 (0.96, 2.03) | |||
| rs2248720 | AC/CC versus AA | 0.053 | 0.86 (0.74, 1.00) | |||
| rs2252585 | CC versus TT | 0.057 | 1.20 (0.94, 1.53) | |||
| rs8134179 | CC versus TT | 0.060 | 0.71 (0.48, 1.06) | |||
| rs2834670 | GG versus AA | 0.097 | 1.14 (0.85, 1.53) | |||
| rs2242878 | CT/TT versus CC | 0.011 | 1.20 (1.04, 1.38) | |||
| rs7279123 | CT/TT versus CC | 0.015 | 1.18 (1.03, 1.35) | |||
| SMAD2 | 0.044 | rs1787199 | TT versus AA | 0.028 | 1.24 (1.03, 1.51) | |
| rs4940086 | CC versus TT | 0.019 | 1.33 (1.06, 1.66) | |||
| SMAD3 | 0.015 | rs12904944 | AA versus GG | 0.069 | 0.81 (0.64, 1.01) | |
| rs1498506 | CC versus AA | 0.0003 | 0.69 (0.57, 0.84) | |||
| rs12901071 | GG versus AA | 0.004 | 0.67 (0.53, 0.84) | |||
| rs2414937 | CC versus GG/GC | 0.034 | 0.68 (0.47, 0.97) | |||
| SMAD7 | 0.045 | rs4939827 | TC/CC versus TT | 0.028 | 0.84 (0.73, 0.98) | |
| rs12953717 | TT versus CC | 0.003 | 1.36 (1.12, 1.65) | |||
| TGFB1 | 0.000 | rs4803455 | AA versus CC | 0.0003 | 1.43 (1.18, 1.74) | |
| rs1800469 | AA versus GG | 0.001 | 0.66 (0.52, 0.85) | |||
| TGFBR1 | 0.087 | rs6478974 | TA/AA versus TT | 0.037 | 0.85 (0.74, 0.99) | |
| rs1571590 | GG versus AA/AG | 0.049 | 1.41 (1.00, 1.98) | |||
| TNF | TNF | 0.036 | rs1799964 | CC versus TT | 0.055 | 1.29 (0.94, 1.76) |
| rs1800630 | CA/AA versus CC | 0.020 | 1.19 (1.03, 1.38) |
Genes with P ARTP <0.05 are indicated in bold.
a P values based on 1-df Wald chi-square tests.
bModels adjusted for age, study center, race/ethnicity and sex.