Table IV.
Associations between subpathway genes and SNPs with rectal cancer that were used in polygenic score (P ARTP < 0.10)
| Subpathway | Gene | Gene P ARTP | SNP | Genotype | SNP P a | OR 95% CIb |
|---|---|---|---|---|---|---|
| Angiogenesis | MPO | 0.041 | rs2243828 | AG/GG versus AA | 0.039 | 0.81 (0.67, 0.99) |
| VEGFA | 0.057 | rs2010963 | GC/CC versus GG | 0.007 | 1.30 (1.07, 1.58) | |
| Hormone/insulin/ growth | IGF1R | 0.079 | IGF1R | CC versus AA | 0.078 | 1.51 (0.93, 2.43) |
| Interferons | IFNGR1 | 0.052 | rs3799488 | CC versus TT/TC | 0.040 | 2.30 (1.04, 5.08) |
| rs9376267 | CT/TT versus CC | 0.065 | 1.20 (0.99, 1.46) | |||
| IRF2 | 0.072 | rs3775554 | CC versus GG | 0.057 | 1.06 (0.46, 2.44) | |
| rs3775556 | GG versus AA | 0.007 | 1.48 (1.00, 2.20) | |||
| rs10009261 | TT versus CC | 0.038 | 0.77 (0.57, 1.04) | |||
| rs7677486 | TT versus CC | 0.003 | 1.54 (1.16, 2.03) | |||
| rs6827018 | GG versus AA | 0.032 | 1.70 (0.75, 3.83) | |||
| rs3733473 | AA versus GG | 0.078 | 0.97 (0.61, 1.53) | |||
| rs3775574 | AG/GG versus AA | 0.003 | 0.74 (0.60, 0.90) | |||
| Interleukins | IL15 | 0.064 | rs12508866 | TC/CC versus TT | 0.019 | 0.79 (0.65, 0.96) |
| rs17461269 | TA/AA versus TT | 0.025 | 1.25 (1.03, 1.52) | |||
| rs13117878 | TT versus CC | 0.066 | 1.29 (0.98, 1.69) | |||
| IL8RA | 0.006 | rs1008562 | GG versus CC | 0.001 | 1.57 (1.20, 2.05) | |
| IL8RB | 0.002 | rs1126579 | TT versus CC | 0.001 | 1.56 (1.19, 2.05) | |
| Jak/Stat/Socs | STAT3 | 0.083 | rs2293152 | CC versus GG/GC | 0.014 | 0.71 (0.54, 0.93) |
| STAT6 | 0.100 | rs3024979 | TA/AA versus TT | 0.016 | 0.73 (0.56, 0.94) | |
| MAPK | DUSP1 | 0.030 | rs322351 | TT versus CC | 0.013 | 1.43 (1.09, 1.88) |
| DUSP7 | 0.051 | rs9851576 | AG/GG versus AA | 0.054 | 0.81 (0.66, 1.00) | |
| MAPK8 | 0.055 | rs10508901 | AA versus CC/CA | 0.023 | 1.45 (1.05, 1.99) | |
| Pathway core | NFKB1 | 0.017 | rs230510 | TT versus AA | 0.006 | 0.67 (0.50, 0.90) |
| rs3821958 | GG versus AA | 0.043 | 1.35 (1.02, 1.78) | |||
| rs11722146 | AA versus GG | 0.015 | 1.42 (1.02, 1.97) | |||
| PIK3CA | 0.077 | rs2699905 | GA/AA versus GG | 0.054 | 0.82 (0.67, 1.00) | |
| rs7651265 | GG versus AA | 0.063 | 2.38 (1.04, 5.43) | |||
| rs7640662 | GG versus CC | 0.012 | 0.30 (0.11, 0.79) | |||
| PIK3CG | 0.019 | rs4460309 | TT versus CC | 0.005 | 0.66 (0.43, 1.00) | |
| rs11766675 | GG versus AA | 0.003 | 0.57 (0.34, 0.96) | |||
| RPS6KA2 | 0.072 | rs10946164 | CT/TT versus CC | 0.020 | 0.78 (0.64, 0.96) | |
| rs9347128 | GG versus CC/CG | 0.027 | 1.32 (1.03, 1.68) | |||
| rs1040446 | TG/GG versus TT | 0.038 | 0.78 (0.61, 0.99) | |||
| rs6911624 | AA versus GG | 0.002 | 0.55 (0.31, 0.98) | |||
| rs4709127 | TT versus CC | 0.047 | 0.74 (0.52, 1.06) | |||
| rs2345067 | CC versus TT | 0.035 | 0.75 (0.57, 0.98) | |||
| rs1202621 | CC versus AA | 0.073 | 1.25 (0.93, 1.68) | |||
| rs7745781 | AG/GG versus AA | 0.001 | 1.42 (1.15, 1.76) | |||
| RPS6KB2 | 0.057 | rs1638588 | AA versus CC | 0.028 | 0.73 (0.56, 0.96) | |
| TSC1 | 0.043 | rs13295634 | GG versus TT/TG | 0.004 | 0.61 (0.43, 0.86) | |
| Selenoproteins | SEPN1 | 0.002 | rs718391 | GG versus CC | 0.010 | 0.70 (0.53, 0.93) |
| rs2072749 | GG versus AA | 0.003 | 0.53 (0.35, 0.80) | |||
| rs11247735 | AA versus GG/GA | 0.021 | 1.31 (1.04, 1.64) | |||
| rs4659382 | GG versus CC/CG | 0.007 | 0.58 (0.39, 0.86) | |||
| SEPP1 | 0.092 | rs3877899 | AA versus GG | 0.039 | 0.68 (0.43, 1.07) | |
| rs11959466 | GA/AA versus GG | 0.019 | 1.46 (1.06, 2.00) | |||
| rs28919882 | AG/GG versus AA | 0.023 | 0.72 (0.55, 0.96) | |||
| TXNRD3 | 0.004 | rs4679274 | TT versus CC/CT | 0.034 | 0.73 (0.54, 0.98) | |
| rs9637365 | TT versus CC/CT | 0.006 | 0.70 (0.55, 0.90) | |||
| rs11718498 | GA/AA versus GG | 0.001 | 1.42 (1.15, 1.74) | |||
| TGFβ | BMPR2 | 0.026 | rs4675278 | AA versus GG | 0.087 | 1.29 (0.92, 1.81) |
| rs17199235 | AG/GG versus AA | 0.018 | 1.35 (1.05, 1.72) | |||
| rs2228545 | GA/AA versus GG | 0.002 | 1.93 (1.28, 2.91) | |||
| TNF | NFAT5 | 0.030 | rs12447326 | TT versus CC/CT | 0.003 | 0.60 (0.43, 0.84) |
| rs16959025 | GG versus TT/TG | 0.025 | 0.57 (0.35, 0.93) |
Significant genes with P ARTP <0.05 are indicated in bold.
a P values based on 1-df Wald chi-square tests.
bModels adjusted for age, study center, race/ethnicity and sex.