. 2014 Oct 20;36(1):49–59. doi: 10.1093/carcin/bgu213

Table V.

Associations for subpathway and gene by tumor molecular phenotype

Subpathway	CIMP			Kras			TP53			MSI
Subpathway	Subpathway P _ARTP	Gene	Gene P _ARTP	Subpathway P _ARTP	Gene	Gene P _ARTP	Subpathway P _ARTP	Gene	Gene P _ARTP	Subpathway P _ARTP	Gene	Gene P _ARTP
Colon cancer^a
Angiogenesis	0.251	SOD1	0.017	0.672			0.875			0.104	MMP7	0.011
											SOD1	0.016
Hormone/insulin/ growth	0.380			0.169	EGR2	0.019	0.069	PPARG	0.037	0.156	IRS1	0.027
					VDR	0.019		TCF7L2	0.003		PPARG	0.019
Interferon	0.422	IRF6	0.029	0.264	IRF6	0.037	0.687			0.812
Interleukins	0.046	IL15	0.032	0.192	IL17A	0.031	0.621			0.628
		IL1A	0.033
		IL6R	0.027
		IL8	0.017
Jak/Stat/Socs	0.234	SOCS2	0.015	0.043	JAK2	0.041	0.022	STAT1	0.023	0.275	SOCS2	0.019
					STAT5B	0.014		STAT5A	0.008
					STAT6	0.007		STAT5B	0.013
Pathway core	0.514	PRKAA1	0.045	0.555	PRKAA1	0.032	0.190	MTOR	0.016	0.192	MTOR	0.005
		TSC1	0.031					PRKAA1	0.009
MAPK	0.039	DUSP2	0.036	0.568			0.640			0.366	MAP3K9	0.017
		MAP3K9	0.001
Selenoprotein	0.751			0.487	C11orf31	0.048	0.845			0.680
Telomere	0.253			0.265			0.149			0.419
TGFβ	0.181	BMP4	0.019	0.027	BMPR1B	0.028	0.007	EIF4EBP3	0.008	0.194	BMPR2	0.039
		RUNX2	0.042		RUNX2	0.015		RUNX3	0.003		TGFB1	0.017
		SMAD2	0.031		TGFB1	0.004		TGFB1	0.004
TLR	0.371			0.780			0.509			0.163	TLR4	0.041
TNF	0.588			0.322			0.971			0.073	TNFRSF1A	0.042
Rectal cancer^b
Angiogenesis	0.478			0.849			0.216	MSTN	0.042
								VEGFA	0.014
Hormone/insulin/ growth	0.781			0.975			0.870
Interferon	0.655			0.818			0.608
Interleukin	0.902			0.282	IL8RB	0.028	0.024	IL6	0.034
								IL8	0.050
								IL8RA	0.013
								IL8RB	0.004
Jak/Stat/Socs	0.305			0.456			0.561
Pathway core	0.529	AKT1	0.026	0.890			0.590	NFKB1	0.050
		NFKB1	0.041					PTEN	0.044
MAPK	0.794			0.260	RAF1	0.030	0.122	DUSP1	0.050
								DUSP6	0.028
								MAPK8	0.006
Selenoprotein	0.801			0.066	SEPN1	0.008	0.033	SEP15	0.029
					SEPX1	0.043		TXNRD2	0.016
								TXNRD3	0.015
Telomere	0.134			0.622			0.146
TGFβ	0.491	TGFBR1	0.024	0.956			0.413	BMP2	0.021
TLR	0.210			0.897			0.679
TNF	0.259			0.763			0.678

^aPathway P _ARTP values of 0.324 for CIMP, 0.255 for Kras, 0.063 for TP53 and 0.420 for MSI.

^bPathway P _ARTP values of 0.843 for CIMP, 0.658 for Kras and 0.171 for TP53.