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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Clin Immunol. 2014 Nov 11;156(1):65–73. doi: 10.1016/j.clim.2014.11.003

Figure 1.

Figure 1

PTPN22 does not affect the onset of disease on the BXSB.Yaa background. A) shows male PTPN22 KO and WT BXSB.Yaa survival (WT n=19, KO n=20). B) shows anti-nuclear antibody levels in the serum (WT n=5, KO n=12) C) shows serum anti-chromatin IgG concentration as measured by ELISA for PTPN22 KO and WT BXSB.Yaa mice (WT n=5, KO n=12). D) shows proteinuria concentration measured by Bradford assay (WT n=10, KO n=17). E&F) kidneys were collected, sectioned and scored for glomerulonephritis (each data point represents 1 mouse). Images are representative of the median GN score for each genotype and are PAS and hematoxylin stained (magnification 40x).