Table 1.
Results of Tetraploid-Based Organ-Complementation Method
| 1st cell | 2nd cell | Tetraploid embryo | Dox | TE | Pups (% TE) | Analysis as neonates | Chimeras | With PSC pancreas |
|---|---|---|---|---|---|---|---|---|
| Pdxl KO iPSC | — | WT | — | 147 | 24 (16) | 24 | — | 0 |
| EB3DR | WT | — | 201 | 32 (16) | 9 | 9 | 9 | |
| RT5 | WT | (+) | 60 | 16 (27) | 16 | 12 | 11 | |
| RT5 | WT | (−) | 78 | 12 (15) | 12 | 7 | 7 | |
| CHT5 | WT or EGFP Tg | (+) | 122 | 8 (7) | 7 | 3 | 3 | |
| CHT5 | WT or EGFP Tg | (−) | 248 | 19 (8) | 18 | 6 | 5 | |
| K3 | — | WT | — | 82 | 14 (17) | 5 | — | — |
iPSC, induced pluripotent stem cell; PSC, pluripotent stem cell; TE, transferred embyros; WT, wild type.