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. Author manuscript; available in PMC: 2015 Jan 12.
Published in final edited form as: J Invest Dermatol. 2014 Feb 12;134(8):2202–2211. doi: 10.1038/jid.2014.85

Figure 2. RNA was extracted from 40 FFPE stage II–III primary melanoma specimens, and 53 genes predictive of melanoma progression were identified using elastic net and random forest classifiers.

Figure 2

See Supplementary Figure S1 online for gene selection method. In (a), a bar graph depicts the number of times each of the 53 genes was selected using a leave-8-out cross-validation with bootstrapping. In (b), a mean receiver operating characteristic curve with fivefold cross-validation to predict melanoma progression is shown, mean area under the curve (AUC)=0.92, P<0.001. In (c), distribution of AUC values using a leave-8-out cross-validation with bootstrapping test is shown.