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. Author manuscript; available in PMC: 2015 Jan 12.
Published in final edited form as: Immunity. 2012 Nov 21;37(6):1050–1060. doi: 10.1016/j.immuni.2012.11.001

Figure 1. Csf-1r Signaling Is Critical for LC Homeostasis in Adult Skin.

Figure 1

(A–F) Plots show the percentage and total cell number (±SEM) of LCs among CD45+ epidermal cells in adult mice (A–C, E and F) or neonates on postnatal day (p)1, p5, and p10 (D). Graphs represent data of pooled experiments. *p < 0.05, **p < 0.01, ***p < 0.001 (Student's t test, unpaired). (A) Csf1r−/− and control mice (Csf1r+/− or Csf1r+/+) (n ≥ 3). (B) Csf1op/op and control mice (Csf1op/+ or Csf1+/+) (n = 5). (C) Langerin (Lang) Cre+ × Csf1rfl/fl or control mice (LangCre+ × Csf1rfl/+ or LangCre × Csf1rfl/fl) (n = 4). (D) LangCre+ × Csf1rfl/fl or LangCre × Csf1rfl/fl neonates. On p1, R1 represents LC precursors (Langerin) and R2 represents LCs (Langerin+). p2: n = 6, p5: n ≥ × p10: n ≥ 6. (E) Anti-(α)Csf-1r treated or isotype treated WT mice (n = 6). One representative of at least three individual experiments is shown.

(F) Rosa26-CreERT2+ (CreERT2+) × Csf1rfl/fl and CreERT2− × Csf1rfl/fl mice were treated with tamoxifen and the skin was analyzed 7 days post treatment (n = 2). One representative of two individual experiments is shown.